Desmopressin Spray

Desmopressin nasal spray is used to treat conditions involving excessive urine production, including central diabetes insipidus and selected disorders of fluid balance. It contains desmopressin, a synthetic version of the natural antidiuretic hormone (ADH) that controls how much urine the kidneys produce at night.

Desmopressin nasal spray reduces urine output overnight when prescribed for appropriate clinical indications. It is sometimes prescribed when oral Desmopressin tablets or melts are not suitable, or when nasal delivery is clinically preferred. You can order Desmopressin nasal spray online from Pharmacy Planet after completing a short consultation.

Desmopressin nasal spray is a prescription medicine containing desmopressin, a synthetic analogue of the hormone vasopressin. Unlike natural vasopressin, desmopressin has minimal effect on blood vessels, meaning it does not cause significant vasoconstriction at therapeutic doses. Desmopressin nasal spray is designed to act on the kidneys, where it signals the body to retain water and produce less urine. This makes it suitable for patients with central diabetes insipidus and other clinically assessed disorders affecting urine production.

Desmopressin nasal spray may be prescribed for:

• Central diabetes insipidus.
• Specialist conditions where reducing urine production is clinically appropriate.
• Night-time urination linked to ADH hormone imbalance, where appropriate.

Suitability is always assessed by one of our UK prescribers during the online consultation.

Desmopressin nasal spray works by mimicking the body's natural antidiuretic hormone. At night, some people do not produce enough ADH, which leads to excess urine formation during sleep. Desmopressin nasal spray corrects this imbalance by acting on the kidneys to increase water reabsorption, reducing the volume of urine produced overnight, and supporting better night-time bladder control. This targeted hormone action makes Desmopressin nasal spray effective for managing night-time urine production when used correctly.

Always use Desmopressin nasal spray exactly as advised by one of our UK prescribers.

• The spray is administered into the nostril, not under the tongue.
• Use the spray at bedtime, as directed.
• Avoid drinking fluids from one hour before use until the following morning.
• Use the lowest effective dose prescribed for you.

Limiting fluid intake is essential during treatment to reduce the risk of water retention and low sodium levels.

Desmopressin nasal spray may be suitable for:

• Adults or children with central diabetes insipidus.
• Adults with clinically assessed disorders of urine overproduction under specialist supervision.
• Patients who cannot tolerate oral Desmopressin formulations when nasal administration is clinically appropriate.

Desmopressin nasal spray is not suitable for:

• Children under 5 years of age.
• People with low sodium levels or a history of hyponatraemia.
• Anyone with moderate to severe kidney disease.
• People with uncontrolled heart conditions or fluid balance disorders.
• Anyone allergic to desmopressin or spray ingredients.

Like all medicines, Desmopressin nasal spray can cause side effects, although not everyone experiences them.

Common Side Effects:

• Headache, nasal irritation or congestion, nausea, mild abdominal discomfort

Less Common or Serious Side Effects:

• Fluid retention and unexplained weight gain, swelling of the hands/feet/face, low sodium levels in the blood, severe headache/vomiting/confusion

Stop treatment and seek urgent medical advice if symptoms of water retention or allergic reaction occur.

Desmopressin nasal spray carries a known risk of water retention and hyponatraemia if fluid intake is not controlled. Fluid intake must be restricted overnight. Body weight and sodium levels may need monitoring during treatment. Treatment is reviewed regularly to confirm ongoing need. Desmopressin nasal spray should only be used under prescriber guidance and reviewed at appropriate intervals.

You can buy Desmopressin nasal spray online from Pharmacy Planet after completing a secure online consultation.

1. Complete a secure online consultation.
2. One of our UK prescribers reviews your information.
3. If approved, Desmopressin nasal spray is dispensed by our pharmacy and delivered discreetly to your door.