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Combigan/Brimonidine+Timolol

Combigan eye drop solution is indicated to reduce intraocular pressure in patients with chronic open-angle glaucoma (vision damage due to chronic slow accumulation of fluid pressure inside the eye) or elevated eye pressure when the use of beta-blockers is not sufficient. It’s designed to reduce the production of liquid in the eye and increasing the quantity of liquid that flows out of it. This leads to a decrease in ocular tension, while the eye continues to normally receive its nutrients. The eye contains a transparent aqueous liquid, which brings nutrients to the internal parts of the eye. However, this liquid is constantly eliminated from the eye, which continually produces new liquid to replace it. When this liquid can no longer flow freely, the pressure inside the eye increases, which may also compromise visual ability.

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Combigan/Brimonidine+Timolol
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Please note that whilst you are able to request the medicine strength and size required,
we will only be able to send on approval from our in house pharmacist.

Starts at £37.00
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Pack Price (£)
- - 5ml x 1 Pack 37.00
- - 5ml x 2 Packs 75.00
- - 5ml x 3 Packs 99.00

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Combigan Eye Drops for Glaucoma Treatment and Eye Pressure Control

When one treatment isn't enough to control eye pressure, combining two proven medicines can make a real difference. That's exactly what Combigan eye drops are designed to do.

Combigan drops bring together brimonidine and timolol in a single formula to deliver dual-action IOP reduction. This means stronger, more consistent pressure control for people managing glaucoma or ocular hypertension. For many, it simplifies treatment while improving results.

What Are Combigan Eye Drops Used For?

Combigan eye drops are used to reduce eye pressure in people with glaucoma or ocular hypertension when a single treatment is not enough. Raised pressure inside the eye can gradually damage the optic nerve, affecting vision over time.

These combination glaucoma drops are commonly prescribed for open-angle glaucoma, ocular hypertension therapy, and patients needing stronger glaucoma treatment. They are often recommended when one type of prescription eye drops does not provide enough control.

How Combigan Eye Drops Work

Combigan glaucoma treatment works through two active ingredients that lower eye pressure in different ways. The formula contains brimonidine, which reduces fluid production and increases drainage, and timolol, a beta-blocker that slows fluid production.

This alpha plus beta-blocker combination provides reduced fluid production inside the eye and improved fluid outflow. Together, they deliver effective dual-action IOP reduction, making Combigan glaucoma therapy stronger than single treatments.

How to Use Combigan Eye Drops

Combigan drops are usually applied twice daily, about 12 hours apart.

  • Wash your hands before use.
  • Tilt your head back and pull down your lower eyelid.
  • Apply one drop into the affected eye.
  • Close your eye and press gently at the inner corner for about 2 minutes.

Leave at least 5 minutes between different eye drops. Do not touch the dropper tip to your eye or skin. Remove contact lenses before use and wait 15 minutes before reinserting. Use consistently for effective eye pressure control. Do not stop using the drops suddenly, and attend regular eye pressure checks.

Your prescriber will explain everything during your consultation at Pharmacy Planet.

Who Can Use Combigan Eye Drops?

Combigan eye drops are suitable for adults who need combination treatment for glaucoma or ocular hypertension. They are typically prescribed for adults with uncontrolled eye pressure on single therapy, patients switching to combination glaucoma drops, and individuals requiring long-term glaucoma treatment.

This medication may not be suitable if you are allergic to brimonidine and timolol or beta-blockers, have asthma or severe breathing conditions, have certain heart conditions such as slow heart rate or heart failure, or are under 18 years of age. Caution is needed if you have diabetes, thyroid disorders, circulation problems, or a history of severe allergies.

Possible Side Effects of Combigan Eye Drops

Like all glaucoma therapy, Combigan may cause side effects.

Common Side Effects:

  • Redness or irritation in the eye
  • Stinging or burning sensation
  • Dry eyes or watery eyes
  • Blurred vision
  • Feeling tired or drowsy

Serious Side Effects — Seek medical attention if you notice:

  • Breathing difficulties
  • Irregular or slow heartbeat
  • Chest discomfort
  • Severe allergic reactions such as swelling or rash

Since this is an alpha plus beta blocker combination, some effects may be felt beyond the eye. Combigan may interact with beta-blockers or heart medications, antidepressants such as MAO inhibitors, medicines for blood pressure, other glaucoma treatments, and sedatives or anxiety medications. Always provide a full medication list during your consultation.

Why Do People Choose to Buy Combigan Eye Drops?

Combigan drops are chosen for their powerful dual-action approach to lowering eye pressure. People often prefer this treatment because it combines two active ingredients in one bottle, delivers strong dual-action IOP reduction, reduces the need for multiple eye drops, is widely used as an effective glaucoma treatment, and supports consistent ocular hypertension therapy. For many patients, Combigan offers a more convenient and effective way to manage eye pressure.

How Does the Ordering Process Work at Pharmacy Planet?

Getting Combigan eye drops online from Pharmacy Planet is simple and clinically guided.

  1. Complete a short consultation and provide details about your eye condition and medical history.
  2. A UK-registered prescriber assesses your suitability.
  3. If approved, your Combigan eye drops are delivered safely to your home.
Combigan Eye Drops

Combigan combines brimonidine (reduces fluid production and increases drainage) and timolol (beta-blocker, reduces fluid production) for dual-action IOP reduction — stronger, more consistent control than single treatments.

Used for open-angle glaucoma, ocular hypertension, and patients needing stronger combination glaucoma treatment when a single drop provides insufficient pressure control.

Brimonidine (alpha-agonist) reduces fluid production and improves drainage; timolol (beta-blocker) reduces fluid production. Together this alpha plus beta-blocker combination delivers effective dual-action IOP reduction.

Twice daily, about 12 hours apart. Wash hands, tilt head, apply one drop, press inner corner for 2 minutes. Leave 5+ minutes between different eye drops; remove contacts before use and reinsert after 15 minutes.

Suitable for adults with uncontrolled eye pressure on single therapy, those switching to combination glaucoma drops, or needing long-term glaucoma treatment.

Not suitable for allergy to brimonidine/timolol or beta-blockers, asthma/severe breathing conditions, certain heart conditions, or under 18s. Caution for diabetes, thyroid disorders, circulation problems, or severe allergy history.

Common: Eye redness/irritation, stinging/burning, dry or watery eyes, blurred vision, tiredness/drowsiness

Serious: Seek medical attention for breathing difficulties, irregular/slow heartbeat, chest discomfort, or severe allergic reactions (swelling/rash)

Two active ingredients in one bottle delivering strong dual-action IOP reduction, reducing the need for multiple drops, and supporting consistent long-term ocular hypertension therapy.

Getting Combigan eye drops online from Pharmacy Planet is simple and clinically guided.

  1. Complete a short consultation and provide details about your eye condition and medical history.
  2. A UK-registered prescriber assesses your suitability.
  3. If approved, your Combigan eye drops are delivered safely to your home.
Frequently Asked Questions

Combigan is usually prescribed when one eye drop does not lower eye pressure enough. It combines two medicines to give stronger and more consistent control.

Combigan starts working within a few hours, but the full pressure-lowering effect builds over several days with regular twice-daily use.

Yes, Combigan can be used with other eye drops if needed. Leave at least 5 minutes between drops to ensure each one works properly.

A mild burning or stinging sensation is common when first using the drops. This usually settles quickly, but ongoing irritation should be checked.

Yes, because they contain timolol, they may slow heart rate or affect breathing. This is why they are not suitable for some heart or lung conditions.

Use the missed dose as soon as you remember, unless it is close to your next dose. Do not use two doses at the same time.

Yes, some people may feel tired or slightly drowsy after using Combigan. If this happens, avoid driving until you feel normal again.

Combigan combines two medicines in one bottle, making treatment simpler. It also ensures both ingredients work together at the same time for better pressure control.

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Review By

GURDEV SEHMI

Last Updated On : Mar 13 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925

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Authored By

GURDEV SEHMI

Last Reviewed On : Mar 23 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925