Mysimba is a prescription medication designed to aid weight management in adults who struggle with obesity or overweight conditions. The active ingredients in Mysimba are naltrexone and bupropion, which work together to influence the brain's appetite and reward system. Naltrexone is traditionally used to treat addiction by reducing the desire for certain substances, while bupropion is an antidepressant that also helps curb food cravings.
This combination medication is thought to act on the central nervous system to regulate appetite and reduce the consumption of high-calorie foods. Mysimba is typically prescribed as part of a comprehensive weight loss program, which includes a balanced diet and regular exercise. It is not a standalone solution but rather a tool to support individuals in their efforts to achieve and maintain a healthier weight.
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Mysimba is used as a weight loss treatment and the effectiveness depends on many factors such as age, diet, exercise, health condition, etc. Clinical studies have shown that patients using Mysimba lost weight between 3.7% and 5.7% of their body weight which is higher when compared to a smaller loss of 1.3% to 1.9% in those taking a placebo. Taking Mysimba tablets regularly along with low-calorie food and involving in physical activity will help to achieve the best results.
If you are taking Mysimba for the first time, it is better to start with one tablet per day in the morning. After having the medication for four weeks continuously, then increase the dose to two tablets for each day. However, it is advised to take the medication as prescribed by the doctor.
Like any other weight loss medication, using Mysimba (naltrexone/bupropion) can cause side effects which will vary from mild to Severe.
MySimba users may experience common side effects like nausea or vomiting, Constipation and Headaches. Others may also experience anxiety, dizziness, altered taste, Hot flashes, Stomach Pain, Excessive sweating, increased blood pressure, irregular heartbeat etc
If you experience any of these side effects, they are often temporary and disappear on their own after a few days.
In a few cases, the side effects can be severe and may require immediate medical attention. It includes
When taken with antidepressants, it can cause agitation, hallucinations, high fever, stiff muscles and serious stomach problems.
You must reduce the intake of foods like processed sugars, fried foods, excessive alcohol, and fizzy drinks instead of cutting things out completely. By having it in smaller portions every day, it helps to easily manage your cravings and hunger
Using Saxenda along with blood-sugar-lowering medications may cause hypoglycaemia as it increases insulin secretion and insulin sensitivity. So, it is important to eat healthy foods and monitor your blood sugar levels to ensure they are within an optimal range.
If you are looking to switch from Mysimba to Wegovy, Mounjaro, Orlistat or Saxenda then you must stop taking the medication for a few days to ensure that the medication is gone completely out of the system. You must consult your healthcare provider to check and suggest the appropriate weight loss medication.
Using Mysimba tablets along with certain medications may increase the risk of side effects when taken alongside Mysimba. These include treatments for depression, high blood pressure, heart issues, Parkinson's disease, cancer, stroke, HIV, and epilepsy. If you are taking medications for any health conditions, you must discuss and understand the potential side effects caused by drug interactions before considering Mysimba for weight loss.
You can choose Mysimba if you find taking oral medication is a more convenient option and are concerned with cravings. However, if you have difficulty swallowing tablets and you are looking to control your hunger, then Saxenda is the perfect choice. Although these two medications are effective for weight loss, Saxenda may result in slightly more weight loss on average.
Mysimba is used as a weight loss treatment and the effectiveness depends on many factors such as age, diet, exercise, health condition, etc. Clinical studies have shown that patients using Mysimba lost weight between 3.7% and 5.7% of their body weight which is higher when compared to a smaller loss of 1.3% to 1.9% in those taking a placebo. Taking Mysimba tablets regularly along with low-calorie food and involving in physical activity will help to achieve the best results.
If you are taking Mysimba for the first time, it is better to start with one tablet per day in the morning. After having the medication for four weeks continuously, then increase the dose to two tablets for each day. However, it is advised to take the medication as prescribed by the doctor.
Like any other weight loss medication, using Mysimba (naltrexone/bupropion) can cause side effects which will vary from mild to Severe.
MySimba users may experience common side effects like nausea or vomiting, Constipation and Headaches. Others may also experience anxiety, dizziness, altered taste, Hot flashes, Stomach Pain, Excessive sweating, increased blood pressure, irregular heartbeat etc
If you experience any of these side effects, they are often temporary and disappear on their own after a few days.
In a few cases, the side effects can be severe and may require immediate medical attention. It includes
When taken with antidepressants, it can cause agitation, hallucinations, high fever, stiff muscles and serious stomach problems.
You must reduce the intake of foods like processed sugars, fried foods, excessive alcohol, and fizzy drinks instead of cutting things out completely. By having it in smaller portions every day, it helps to easily manage your cravings and hunger
Using Saxenda along with blood-sugar-lowering medications may cause hypoglycaemia as it increases insulin secretion and insulin sensitivity. So, it is important to eat healthy foods and monitor your blood sugar levels to ensure they are within an optimal range.
If you are looking to switch from Mysimba to Wegovy, Mounjaro, Orlistat or Saxenda then you must stop taking the medication for a few days to ensure that the medication is gone completely out of the system. You must consult your healthcare provider to check and suggest the appropriate weight loss medication.
Using Mysimba tablets along with certain medications may increase the risk of side effects when taken alongside Mysimba. These include treatments for depression, high blood pressure, heart issues, Parkinson's disease, cancer, stroke, HIV, and epilepsy. If you are taking medications for any health conditions, you must discuss and understand the potential side effects caused by drug interactions before considering Mysimba for weight loss.
You can choose Mysimba if you find taking oral medication is a more convenient option and are concerned with cravings. However, if you have difficulty swallowing tablets and you are looking to control your hunger, then Saxenda is the perfect choice. Although these two medications are effective for weight loss, Saxenda may result in slightly more weight loss on average.
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* Results are not directly comparable because studies differed. Figures are approximate and treatment was combined with a calorie deficit and increased physical activity. Results vary depending on the individual.
Generally, it is advisable to take a Mysimba tablet along with the food rather than on an empty stomach as it can help to reduce the chances of getting side effects like nausea, vomiting etc
Yes, a few patients have reported that when using Mysimba they have experienced side effects such as insomnia or disturbed sleep. The active ingredients used in this medication may influence sleeping patterns.
MySimba contains Bupropion which can be used in the treatment of depression in a few places. It is not recommended to use due to potential drug interactions. When it is taken along with other antidepressants, it can cause dangerous side effects like an increased risk of seizures, serotonin syndrome, etc.
When you stop taking Mysimba, there is a chance that you can regain the weight that was lost during the medication period. This is because Mysimba helped in decreasing appetite and cravings, resulting in reduced food intake. It is important to carry out changes in lifestyle activities. This will help in maintaining your weight.
Yes, Mysimba helps in regulating the appetite and makes you feel less hungry. The active ingredient naltrexone in MySimba targets and controls the brain areas which are responsible for hunger and cravings. If you have eating disorders, then it is better to inform your doctor before you begin the medication course.
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Review By
HARMINDER ‘HARMY’ KAUR
Last Updated On : Mar 13 2026
BSc(hons) Pharmacy
GPhC Number: 2061107
Authored By
GURDEV SEHMI
Last Reviewed On : Mar 23 2026
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
GPhC Number: 2050925
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