Novofem
Novofem is a medicine used for menopausal symptoms. The active ingredients in Novofem, estradiol (an estrogen hormone) and norethisterone (a luteal hormone), restore the hormonal levels and therefore alleviate the symptoms of menopause. Novofem is prescribed as Hormone Replacement Therapy (HRT) for menopausal women. This medication is only available with a prescription. You can buy Novofem tablets online in the UK from Pharmacy Planet, and we offer only genuine medications to our customers.
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| Pack | Price (£) | ||
|---|---|---|---|
| - | - | 84 Tablets | 39.00 |
| - | - | 168 Tablets | 74.00 |
| - | - | 252 Tablets | 106.00 |
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What is Novofem?
Novofem is a form of estrogen, a female sex hormone that regulates many processes in the body. Norethindrone is a form of progesterone, an important female hormone to regulate ovulation and menstruation. Novofem is a combination medicine used to treat menopausal symptoms, such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Novofem and norethindrone can also be used for purposes not mentioned in the Novofem guide.
How does it work?
Estradiol: The active substance, synthetic 17b-estradiol, is chemically and biologically identical to endogenous human estradiol. It replaces the loss of estrogen production that occurs during the postmenopause of women and alleviates the symptoms of menopause. Estrogens prevent bone loss due to menopause or ovariectomy.
Norethisterone acetate: Synthetic progestin. Estrogens promote the growth of the endometrium, whereby unopposed estrogens increase the risk of hyperplasia and endometrium cancer. Adding a progestogen reduces the risk of endometrial hyperplasia induced by estrogens in non-hysterectomised women.
What are the benefits of taking it?
Novofem Tablet uses and benefits include being indicated for the treatment of menopausal symptoms. This includes:
- Hot flushes;
- Excessive sweating, night sweats;
- Vaginal dryness and dry mouth and/or eyes;
- Anxiety;
- Mood swings or depression
- Sleep disorders;
- Decreased sexual desire;
- Bone loss (osteoporosis).
In addition to estradiol (to reduce menopausal symptoms), Novofem also contains norethisterone. This substance protects the uterus from the side effects that can be caused by the administration of estradiol. Novofem is particularly suitable for women who still have (irregular) periods and whose uterus is still present.
How do I use it and its dosage?
Always take these HRT tablets exactly as your doctor tells you. Consult your doctor or pharmacist if you have questions.
If you are not taking any other hormone replacement therapy, treatment with Novofem can start it on the day that you consider convenient. If you are already taking other types of hormone replacement therapy, your doctor will tell you when to start the Novofem treatment.
One tablet will be taken once a day, at approximately the same time each day.
Each box contains 28 tablets
- Days 1-16 Take one red tablet every day for 16 days
- Days 17-28 Take one white tablet every day for 12 days
Take the tablets with a glass of water.
Once you have finished the box, start a new one by continuing the treatment without interruption.
Menstruation (period) bleeding usually occurs at the beginning of a new box.
Check with your doctor if you do not show improvement after 3 months of treatment. You should only continue treatment when the benefit outweighs the risk.
If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Novofem and norethindrone.
Your doctor should check your progress regularly (every 3 to 6 months) to determine if you should continue with this treatment. Self-examine your breasts monthly for lumps and get a mammogram every year while using Novofem and norethindrone.
Store at room temperature, away from moisture, heat, and light.
Side effects & precautions
Like all medicines, this hormone replacement therapy menopause medication can cause side effects, although not all people suffer from them.
The following diseases occur more often in women using HRT in Comparison with women who do not use HRT:
- Breast cancer
- abnormal growth or cancer of the lining of the uterus (endometrial hyperplasia or cancer)
- ovarian cancer
- blood clots in the veins of the legs or lungs (venous thromboembolism)
- heart disease
- stroke
- probable memory loss if HRT starts after 65 years of age
Hypersensitivity/allergy (rare side effect affecting 1 - 10 users due to every 1,000)
Although rare, hypersensitivity / allergy may occur: Signs of hypersensitivity/allergy may include one or more of the following symptoms: hives, itching, swelling, difficulty breathing, low blood pressure (pale and cold skin, rapid heart rate), feeling dizzy, sweating, which may be signs of reaction/shock anaphylactic.
Very common Novofem side effects (may affect more than 1 in 10 people)
- Headache
- Breast pain
Common effects (may affect up to 1 in 10 people)
- Increased blood pressure and worsening hypertension
- Vaginal yeast infection (eg, yeast infection)
- Dizziness, insomnia, depression
- Dyspepsia (indigestion), abdominal pain, flatulence
- Nausea (dizziness)
- Rash, itching
- Vaginal bleeding
- Aggravation of uterine fibroids (benign tumor of the uterus)
- Edema (swelling of hands, wrists, and feet)
- Weight gain
Infrequent effects (may affect up to 1 in 100 people)
- Migraine
- Libido changes (change in sexual desire)
- Peripheral embolism and thrombosis (blood clots)
- Vomiting (dizziness)
- Gallbladder disease or gallstones
Hair loss (alopecia)
- Muscle cramps
Rare effects (may affect up to 1 in 1,000 people)
- Allergic reactions
- Nervousness
- Vertigo (dizziness)
- Diarrhea
- Swollen abdomen
- Acne
- Uterine fibroma (benign tumor of the uterus)
Buying Novofem online
You can buy Novofem tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this HRT medication online, use Pharmacy Planet, a UK pharmacy you can trust.
Will I have bleeding while taking Novofem medication?
Yes, you may experience bleeding once every month while using the Novofem medication at the initial stages. If you experience any spotting or unexpected bleeding (not withdrawal bleeding) for more than six months, then you must consult your healthcare provider immediately.
How Long Does Novofem Take to Work?
This can vary from person to person. Most users begin to notice improvements in symptoms within the first few weeks of using Novofem. However, it may take up to three months to see the full benefit of the medication. If you do not notice any improvements after more than four months, then you must consult your healthcare provider, who may prescribe different medications.
Novofem is a form of estrogen, a female sex hormone that regulates many processes in the body. Norethindrone is a form of progesterone, an important female hormone to regulate ovulation and menstruation. Novofem is a combination medicine used to treat menopausal symptoms, such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Novofem and norethindrone can also be used for purposes not mentioned in the Novofem guide.
Estradiol: The active substance, synthetic 17b-estradiol, is chemically and biologically identical to endogenous human estradiol. It replaces the loss of estrogen production that occurs during the postmenopause of women and alleviates the symptoms of menopause. Estrogens prevent bone loss due to menopause or ovariectomy.
Norethisterone acetate: Synthetic progestin. Estrogens promote the growth of the endometrium, whereby unopposed estrogens increase the risk of hyperplasia and endometrium cancer. Adding a progestogen reduces the risk of endometrial hyperplasia induced by estrogens in non-hysterectomised women.
Novofem Tablet uses and benefits include being indicated for the treatment of menopausal symptoms. This includes:
- Hot flushes;
- Excessive sweating, night sweats;
- Vaginal dryness and dry mouth and/or eyes;
- Anxiety;
- Mood swings or depression
- Sleep disorders;
- Decreased sexual desire;
- Bone loss (osteoporosis).
In addition to estradiol (to reduce menopausal symptoms), Novofem also contains norethisterone. This substance protects the uterus from the side effects that can be caused by the administration of estradiol. Novofem is particularly suitable for women who still have (irregular) periods and whose uterus is still present.
Always take these HRT tablets exactly as your doctor tells you. Consult your doctor or pharmacist if you have questions.
If you are not taking any other hormone replacement therapy, treatment with Novofem can start it on the day that you consider convenient. If you are already taking other types of hormone replacement therapy, your doctor will tell you when to start the Novofem treatment.
One tablet will be taken once a day, at approximately the same time each day.
Each box contains 28 tablets
- Days 1-16 Take one red tablet every day for 16 days
- Days 17-28 Take one white tablet every day for 12 days
Take the tablets with a glass of water.
Once you have finished the box, start a new one by continuing the treatment without interruption.
Menstruation (period) bleeding usually occurs at the beginning of a new box.
Check with your doctor if you do not show improvement after 3 months of treatment. You should only continue treatment when the benefit outweighs the risk.
If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Novofem and norethindrone.
Your doctor should check your progress regularly (every 3 to 6 months) to determine if you should continue with this treatment. Self-examine your breasts monthly for lumps and get a mammogram every year while using Novofem and norethindrone.
Store at room temperature, away from moisture, heat, and light.
Like all medicines, this hormone replacement therapy menopause medication can cause side effects, although not all people suffer from them.
The following diseases occur more often in women using HRT in Comparison with women who do not use HRT:
- Breast cancer
- abnormal growth or cancer of the lining of the uterus (endometrial hyperplasia or cancer)
- ovarian cancer
- blood clots in the veins of the legs or lungs (venous thromboembolism)
- heart disease
- stroke
- probable memory loss if HRT starts after 65 years of age
Hypersensitivity/allergy (rare side effect affecting 1 - 10 users due to every 1,000)
Although rare, hypersensitivity / allergy may occur: Signs of hypersensitivity/allergy may include one or more of the following symptoms: hives, itching, swelling, difficulty breathing, low blood pressure (pale and cold skin, rapid heart rate), feeling dizzy, sweating, which may be signs of reaction/shock anaphylactic.
Very common Novofem side effects (may affect more than 1 in 10 people)
- Headache
- Breast pain
Common effects (may affect up to 1 in 10 people)
- Increased blood pressure and worsening hypertension
- Vaginal yeast infection (eg, yeast infection)
- Dizziness, insomnia, depression
- Dyspepsia (indigestion), abdominal pain, flatulence
- Nausea (dizziness)
- Rash, itching
- Vaginal bleeding
- Aggravation of uterine fibroids (benign tumor of the uterus)
- Edema (swelling of hands, wrists, and feet)
- Weight gain
Infrequent effects (may affect up to 1 in 100 people)
- Migraine
- Libido changes (change in sexual desire)
- Peripheral embolism and thrombosis (blood clots)
- Vomiting (dizziness)
- Gallbladder disease or gallstones
Hair loss (alopecia)
- Muscle cramps
Rare effects (may affect up to 1 in 1,000 people)
- Allergic reactions
- Nervousness
- Vertigo (dizziness)
- Diarrhea
- Swollen abdomen
- Acne
- Uterine fibroma (benign tumor of the uterus)
You can buy Novofem tablets online through one of the UK’s leading online pharmacies, Pharmacy Planet. It's easy and convenient. You will need to fill out a short assessment and the item will be delivered directly to your door. If you want to buy this HRT medication online, use Pharmacy Planet, a UK pharmacy you can trust.
Yes, you may experience bleeding once every month while using the Novofem medication at the initial stages. If you experience any spotting or unexpected bleeding (not withdrawal bleeding) for more than six months, then you must consult your healthcare provider immediately.
This can vary from person to person. Most users begin to notice improvements in symptoms within the first few weeks of using Novofem. However, it may take up to three months to see the full benefit of the medication. If you do not notice any improvements after more than four months, then you must consult your healthcare provider, who may prescribe different medications.
If you think Novofem is not suitable and you are looking for alternative medications, the following options can be considered:
- Elleste Duet 1mg
- Femoston 1/10
- Kliofem 2mg/1mg
Novofem tables are available in the following strengths:
- Novofem 1mg/1mg
- Novofem 2mg/1mg
Novofem contains red and white tablets. Red-coated contains estradiol hemihydrate, and white-coated contains both estradiol hemihydrate and norethisterone acetate. The tablets also include inactive ingredients such as magnesium stearate, talc, lactose monohydrate, maize starch, and hydroxypropylcellulose.
Weight gain has been reported in some patients, often due to fluid retention, which is common during menopause. If you notice a steady increase in weight over several months, report this to your healthcare professional, who can assess the cause and recommend appropriate measures.
If you think your symptoms are improving and are considering stopping Novofem, it is important to speak with your healthcare provider first. If you stop immediately without medical advice, then the symptoms may reappear and could result in serious health issues.
Yes, Novofem contains both oestrogen and synthetic progesterone as active ingredients.
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References:
Review By
GURDEV SEHMI
Last Updated On : Mar 13 2026
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
GPhC Number: 2050925
Authored By
GURDEV SEHMI
Last Reviewed On : Mar 23 2026
BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead
GPhC Number: 2050925


