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Komboglyze is a medicine that contains active substances like saxagliptin and metformin and is available in tablets (2.5 mg / 850 mg or 2.5 mg / 1 000 mg). Komboglyze is indicated in addition to diet and exercise to improve glycemic control in patients with type 2 diabetes for whom the glycemic rate is not adequately controlled with metformin alone (another antidiabetic agent) or in those patients who are already receiving the combination. of saxagliptin and metformin in separate tablets. The medicine can only be purchased with a prescription.

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Please note that whilst you are able to request the medicine strength and size required,
we will only be able to send on approval from our in house pharmacist.

Starts at £51.75
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Price Comparison

Select your preferred options and see the best price

Pack Price (£)
- 2.5mg/850mg 56 Tablets 51.75
- 2.5mg/850mg 112 Tablets 103.50
- 2.5mg/850mg 168 Tablets 149.50
- 2.5mg/1000mg 56 Tablets 51.75
- 2.5mg/1000mg 112 Tablets 103.50
- 2.5mg/1000mg 168 Tablets 149.50

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Komboglyze Tablets for Type 2 Diabetes Blood Sugar Control

When your blood sugar remains higher than it should be, even though you are taking metformin regularly, it can feel unsettling. You are doing your part, watching your food and trying to stay active, but the numbers still are not where they need to be.

Komboglyze tablets are often considered at this stage.

How Does Komboglyze Improves Blood Sugar Control?

Komboglyze combines saxagliptin and metformin in one tablet. Saxagliptin belongs to a group called DPP-4 inhibitors. These medicines support your body's natural insulin response after meals. Metformin reduces the amount of sugar released by the liver and improves how your body uses insulin.

Together, they work in different but complementary ways to improve blood sugar control and support long-term glucose management in adults with type 2 diabetes. These are combination diabetes tablets designed to simplify treatment while strengthening your daily oral diabetic therapy.

How Do Komboglyze Tablets Work?

Komboglyze supports sugar control from two angles: saxagliptin increases natural hormones that stimulate insulin release after meals and reduce excess glucose production, while metformin lowers liver glucose output and improves insulin sensitivity. This dual action makes Komboglyze one of the commonly prescribed diabetes combo pills when a single treatment is not enough.

Komboglyze may be prescribed when metformin alone is not providing enough blood sugar control, when you are already taking saxagliptin and metformin separately and want them combined into one tablet, or when you need additional diabetic care alongside insulin or a sulphonylurea. It is used alongside diet and exercise, not instead of them.

How to Take Komboglyze Tablets

Take Komboglyze tablets exactly as prescribed during your consultation with Pharmacy Planet. Take Komboglyze twice daily, always with meals, and swallow the tablet whole with water. Taking it with food reduces stomach side effects linked to metformin.

Your exact dose depends on your current treatment and kidney function. The total daily saxagliptin dose is usually 5 mg, divided into two doses. If you miss a dose, take it when you remember unless it is nearly time for your next dose. Do not take two doses at once.

As metformin is removed through the kidneys, kidney function must be checked before starting treatment and monitored at least once a year. Komboglyze is not suitable if kidney function is severely reduced.

Who Should Not Use Komboglyze Tablets?

Komboglyze tablets are not suitable if you have type 1 diabetes, severe kidney problems, severe hepatic impairment, a history of severe allergic reactions to DPP-4 inhibitors, metabolic acidosis including diabetic ketoacidosis, or if you are breastfeeding. It is not recommended during pregnancy. Insulin is usually preferred.

Possible Side Effects of Komboglyze Tablets

Like all sugar control tablets, Komboglyze can cause side effects. Most are mild, but some require urgent attention.

Common Side Effects:

  • Feeling sick
  • Diarrhoea
  • Stomach discomfort
  • Headache
  • Low blood sugar when used with insulin or sulphonylureas

These often improve as your body adjusts.

Serious Side Effects:

  • Severe and persistent stomach pain, which could indicate pancreatitis
  • Symptoms of lactic acidosis such as muscle cramps, unusual tiredness, breathing difficulty or feeling very cold
  • Swelling of the face, lips or throat
  • Blistering or severe skin reactions

Stop taking the medicine and seek urgent medical care if any of these occur.

Why Do People Choose Komboglyze Tablets?

People prefer Komboglyze because it combines two medicines into one tablet, simplifies daily diabetic care, supports stronger blood sugar control than metformin alone, can be used alongside insulin when needed, and is designed for long-term glucose management. For many people, it represents the next practical step when diabetes needs more support.

How Does the Ordering Process Work at Pharmacy Planet?

Ordering Komboglyze tablets online from Pharmacy Planet is simple and clinically reviewed.

  1. Answer a few medical questions about your type 2 diabetes, current treatment, and overall health.
  2. A UK-registered prescriber checks that Komboglyze is suitable and safe for your blood sugar control.
  3. If approved, your medicine is dispensed by our pharmacy and delivered discreetly to your address.
Komboglyze Tablets

When your blood sugar remains higher than it should be, even though you are taking metformin regularly, it can feel unsettling. Komboglyze tablets are often considered at this stage.

Komboglyze combines saxagliptin and metformin in one tablet to improve blood sugar control and support long-term glucose management in adults with type 2 diabetes.

Komboglyze combines saxagliptin (a DPP-4 inhibitor that supports your body's natural insulin response after meals) and metformin (which reduces sugar released by the liver and improves how your body uses insulin). Together, they work in different but complementary ways to improve blood sugar control.

Saxagliptin increases natural hormones that stimulate insulin release after meals and reduce excess glucose production. Metformin lowers liver glucose output and improves insulin sensitivity. This dual action makes Komboglyze one of the commonly prescribed diabetes combo pills when a single treatment is not enough.

Take twice daily with meals, swallowed whole with water. The total daily saxagliptin dose is usually 5 mg, divided into two doses. Do not take two doses at once if a dose is missed.

Kidney function must be checked before starting and monitored at least once a year. Not suitable if kidney function is severely reduced.

Not suitable if you have: type 1 diabetes, severe kidney problems, severe hepatic impairment, history of severe allergic reactions to DPP-4 inhibitors, metabolic acidosis including diabetic ketoacidosis, or if you are breastfeeding. Not recommended during pregnancy.

Common Side Effects:

  • Feeling sick, diarrhoea, stomach discomfort, headache, low blood sugar with insulin or sulphonylureas

Serious Side Effects:

  • Severe and persistent stomach pain (possible pancreatitis)
  • Lactic acidosis symptoms (muscle cramps, unusual tiredness, breathing difficulty, feeling very cold)
  • Swelling of the face, lips or throat
  • Blistering or severe skin reactions

Stop taking and seek urgent medical care if any of these occur.

People prefer Komboglyze because it combines two medicines into one tablet, simplifies daily diabetic care, supports stronger blood sugar control than metformin alone, can be used alongside insulin, and is designed for long-term glucose management.

Ordering Komboglyze tablets online from Pharmacy Planet is simple and clinically reviewed.

  1. Answer a few medical questions about your type 2 diabetes, current treatment, and overall health.
  2. A UK-registered prescriber checks that Komboglyze is suitable and safe for your blood sugar control.
  3. If approved, your medicine is dispensed and delivered discreetly to your address.
Frequently Asked Questions

Komboglyze contains saxagliptin and metformin together. Metformin lowers liver sugar production, while saxagliptin improves insulin release after meals. This combination provides stronger blood sugar control than metformin alone.

Yes, Komboglyze contains the same active ingredients. The difference is convenience. It combines both medicines into one tablet, reducing the number of tablets you take daily.

Yes. Komboglyze can be used alongside insulin if blood sugar is still high. Your insulin dose may need adjusting to reduce the risk of low blood sugar.

Komboglyze is generally weight neutral. It does not usually cause weight gain. Metformin may even support modest weight stability in some people with type 2 diabetes.

Severe and constant stomach pain that may spread to your back is the main warning sign. If this happens, stop taking Komboglyze and seek urgent medical attention.

Metformin is cleared through the kidneys. Reduced kidney function increases the risk of lactic acidosis. Blood tests check that Komboglyze is safe for you.

Regular or heavy alcohol use increases the risk of lactic acidosis. Alcohol should be avoided or kept to a minimum while taking Komboglyze.

If you develop severe vomiting, dehydration, or infection, Komboglyze may need to be paused temporarily. Seek medical advice if you feel unusually weak or breathless.

It is usually prescribed when metformin alone is not enough. It is not normally the first treatment given at diagnosis unless advised during specialist review.

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Review By

GURDEV SEHMI

Last Updated On : Mar 13 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925

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Authored By

GURDEV SEHMI

Last Reviewed On : Mar 23 2026

BSc Pharm, MRPharmS, Independent Prescriber, Superintendent Pharmacist, Clinical Lead

GPhC Number: 2050925